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Lee DH, Lee IK, Porta M, Steffes M, Jacobs DR Jr
IGF-1 LR3 (Insulin-like Growth Factor-1 Long R3) is a modified analogue of human IGF-1 with an extended half-life due to an arginine substitution at position 3 and a 13-amino-acid N-terminal extension that reduces binding to IGF-binding proteins
Stevens, Radostin Danev, Denise Wootten and Patrick M
Novo Nordisk presented these results at the European Association for the Study of Diabetes congress in September 2025 and used them to move cagrilintide into a dedicated phase 3 programme, RENEW
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